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Table 1 Characteristics of polymer precursors used for the conjugation of LacdiNAc epitope

From: Biocompatible glyconanomaterials based on HPMA-copolymer for specific targeting of galectin-3

Compound Prepared from Precursor for glycopolymer Functional groups Mn (g/mol)a Ð a
Type Content (mol. %)
10 8, 9 TT 11.4 22,900 1.06
11 8, 9 TT 20.5 25,300 1.13
12 8, 9 TT 31.0 27,700 1.04
13 10 24, 25, 29, 30 Propargyl 10.3 21,400 1.07
14 11 26, 31 Propargyl 20.1 22,700 1.14
15 12 27, 28, 32 Propargyl 29.4 20,700 1.18
16 10 33, 34 DBCO 5.4 21,500 1.22
17 10 35 Ethynylphenyl 9.9 21,200 1.07
18 11 36, 37 Ethynylphenyl 20.2 27,400 1.11
20 8, 19 NH2 8.5 27,500 1.08
23 20 38, 39 Diethynylphenyl 6.8b 31,700 1.11
  1. aMolecular weight (Mn) and dispersity (Ð) of polymer precursors were determined using GPC with RI and MALS detection using TSKgel Super SW3000 column and methanol/0.3 M sodium acetate buffer, pH 6.5 (4/1, v/v) as the mobile phase
  2. b6.8 mol. % is the content of linker molecule corresponding to 13.6 mol. % of ethynylphenyl moieties available for CuAAC