Biocompatible glyconanomaterials based on HPMA-copolymer for specific targeting of galectin-3

Table 1 Characteristics of polymer precursors used for the conjugation of LacdiNAc epitope

Compound	Prepared from	Precursor for glycopolymer	Functional groups		M_n (g/mol)^a	Ð ^a
Compound	Prepared from	Precursor for glycopolymer	Type	Content (mol. %)	M_n (g/mol)^a	Ð ^a
10	8, 9	–	TT	11.4	22,900	1.06
11	8, 9	–	TT	20.5	25,300	1.13
12	8, 9	–	TT	31.0	27,700	1.04
13	10	24, 25, 29, 30	Propargyl	10.3	21,400	1.07
14	11	26, 31	Propargyl	20.1	22,700	1.14
15	12	27, 28, 32	Propargyl	29.4	20,700	1.18
16	10	33, 34	DBCO	5.4	21,500	1.22
17	10	35	Ethynylphenyl	9.9	21,200	1.07
18	11	36, 37	Ethynylphenyl	20.2	27,400	1.11
20	8, 19	–	NH₂	8.5	27,500	1.08
23	20	38, 39	Diethynylphenyl	6.8^b	31,700	1.11

^aMolecular weight (M_n) and dispersity (Ð) of polymer precursors were determined using GPC with RI and MALS detection using TSKgel Super SW3000 column and methanol/0.3 M sodium acetate buffer, pH 6.5 (4/1, v/v) as the mobile phase
^b6.8 mol. % is the content of linker molecule corresponding to 13.6 mol. % of ethynylphenyl moieties available for CuAAC

ISSN: 1477-3155