Fig. 7

Effect of cell viability and survival of the self-nanoemulsifying system. a Effect of berberine solution (BBR) and the system (BBR SNE) on Caco-2 cell viability as evaluated by MTT assays after treatment for 24 h. The data are expressed as the mean ± S.D. (n = 3). b The survival rate of MV4-11 xenograft mice orally administered berberine suspension (BBR), PBS, Blank SNE and the system (BBR SNE) excepted for cytarabine (Ara-C) with the vein intravenous injection at 50 (mg/kg)/day for 14 consecutive days; the same volume of PBS and blank SNE were used as controls. The data are expressed as the mean ± S.D. (n = 10); *P < 0.05, and ***P < 0.001