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Table 2 Apparent permeability coefficients (Papp) and efflux ratio (ER) of berberine and berberine SNE cross Caco-2 monolayer

From: Self-nanoemulsifying system improves oral absorption and enhances anti-acute myeloid leukemia activity of berberine

Group

Papp (×10−8 cm/s)

ER

AP–BL

BL–AP

Berberine

–

2.771 ± 0.213

–

Berberine SNE

0.749 ± 0.116

1.852 ± 0.271**

2.473 ± 0.467

Berberine SNE + Ver

0.232 ± 0.231*

1.325 ± 0.172#

5.711 ± 0.524##

  1. Values are the mean ± SD, n = 3
  2. ER efflux ratio, Papp permeability coefficient, SNE self-nanoemulsifying system, Ver verapamil
  3. * P < 0.05, compared with berberine NE in AP–BL transport
  4. ** P < 0.01, compared with berberine in BL–AP transport
  5. #P < 0.01, compared with berberine NE in BL–AP transport
  6. ##P < 0.01, compared with berberine NE
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Journal of Nanobiotechnology

ISSN: 1477-3155

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