Fig. 5

Neurotoxcity assessment of L4′ liposome. Dextrose (a) or liposome L4′ (b) was injected in tumor-free animals. The liposome L4′ was administered at a lipid concentration equivalent to that of the MTD of the liposome L4. Fifty days post-CED, the histopathological analyses showed that the liposome L4′ didn’t affect brain structures, didn’t activate microglia, and didn’t induce necrosis