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Table 3 Median survival time of F98 glioma bearing Fischer rats

From: Liposomal formulations of carboplatin injected by convection-enhanced delivery increases the median survival time of F98 glioma bearing rats

ID

Drugs

MTD (µg)

MeST (days)

Range

 

Dextrose

23.5

20–25

 

Carboplatin

25

38.5

31–47

L1

Liposomal carboplatin

10

35.0

31–42

L1′

Hollow liposomes

22.5

22–23

L1″

Hollow liposomes

 

L2

Liposomal carboplatin

18a

29.0

25–32

L3

Liposomal carboplatin

38.7a

31.0

28–34

L3′

Hollow liposomes

 

L4

Liposomal carboplatin

50

49.5

31–71

L4′

Hollow liposomes

25

22–26

  1. LD50 lethal dose for 50% of the cells, MeST Median survival time, MTD maximum tolerated dose
  2. aMaximal concentration that can be injected