Fig. 4
In vitro microdialysis and solubility analyses. Linear curve of the drug concentration in the dialysate (Cin) against the drug concentration in the medium outside of the probe membrane (Cout) (a), microdialysis probe recoveries of evodiamine (EVO) and rutaecarpine (RUT) using different perfusates (RS, Ringer’s solution; RS-ME, Ringer’s solution-adjusted microemulsion-based isotonic perfusate; RS-PEG, 20% [v/v] PEG 400 Ringer’s solution; RS-EtOH, 10% [v/v] ethanol Ringer’s solution) (b), solubility of EVO and RUT in the perfusates at 25 °C (c), and NanoSight tracking analysis of the medium treated with the microdialysis probe dialyzed by RS-ME for 10 h (d)