Fig. 7
HA-eNPs/ATRA decreased the tumorigenicity of CD44-enriched B16F10 cells. a Side population (SP) changes in B16F10 cells after treatment with various ATRA formulations. b A diagram of the tumorigenicity assessment. In the experiment, four flanks of each mouse were injected with the same treated or untreated B16F10 cells. c Representative photo of tumors 24 days after subcutaneous implantations of ATRA formulations treated or untreated B16F10 cells (arrows indicate tumor nodules). d, e Tumor occurrences and weights measured 24 day after implantation. Results are shown as the means ± SD (n = 16)