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Fig. 9 | Journal of Nanobiotechnology

Fig. 9

From: Comparative mouse lung injury by nickel nanoparticles with differential surface modification

Fig. 9

Trichrome staining of the lung tissues from mice 42 days after nickel nanoparticle exposure. Mice were instilled intratracheally with 50 µg per mouse of Nano-Ni, or with either partially passivated (Nano-Ni–P) or carbon-coated (Nano-Ni–C) nickel nanoparticles with same molar concentration of Ni as Nano-Ni. Control mice were instilled with physiological saline. A The normal structure of lung parenchyma in a control mouse. D–F Extensive pulmonary fibrosis (collagen deposition, blue staining) in the mice with Nano-Ni exposure. Fibrosis was also observed in Nano-Ni–P-exposed lungs (B), but not in Nano-Ni–C-exposed lungs (C). Scale bar in A represents 50 µm for all panels

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