Fig. 9From: Comparative mouse lung injury by nickel nanoparticles with differential surface modificationTrichrome staining of the lung tissues from mice 42 days after nickel nanoparticle exposure. Mice were instilled intratracheally with 50 µg per mouse of Nano-Ni, or with either partially passivated (Nano-Ni–P) or carbon-coated (Nano-Ni–C) nickel nanoparticles with same molar concentration of Ni as Nano-Ni. Control mice were instilled with physiological saline. A The normal structure of lung parenchyma in a control mouse. D–F Extensive pulmonary fibrosis (collagen deposition, blue staining) in the mice with Nano-Ni exposure. Fibrosis was also observed in Nano-Ni–P-exposed lungs (B), but not in Nano-Ni–C-exposed lungs (C). Scale bar in A represents 50 µm for all panelsBack to article page