Fig. 7

Intranasal immunization with NE-P22 protected mice against H. pylori infection. A Colonization of H. pylori in mice intranasally immunized with P22, P22 plus CpG, NE-P22, NE-P22 plus CpG, NE, NE plus CpG, CpG. The results obtained were compared with CpG. The colonization of H. pylori was quantified by real-time PCR 4 weeks post-challenge (n = 5). b Gastric inflammation scores of mice immunized with peptides were identified 4 weeks after infection (n = 6) and c representative gastric histopathology of immunized, PBS controls and health mice are shown (H&E staining, original magnification ×200). The data are expressed as the mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001