Fig. 3

Therapeutic effects of the indicated formulations (0.9% NaCl (Sham), SPC, OEA and SPC, OEA, OEA–SPC, and OEA–SPC NPs, [OEA] = 10.0 mg/kg, [SPC] = 44.6 mg/kg) on cerebral damage after MCAO in mice. The infarct volume (A, D), oedema degree (E), number of neurons (B, F) and number of Iba-1⁺ cells (C, G) were detected at 24 h after reperfusion in mice. OEA and SPC: The mixture of OEA and SPC; OEA–SPC: The OEA–SPC complex. “a–e” in B, C, F, and G represent Sham, MCAO, OEA, OEA–SPC, and OEA–SPC NPs, respectively. Bar in figure B is 100 µm, and bar in figure C is 100 µm. Data are expressed as mean ± SD. *P < 0.01 VS. MCAO group