Fig. 6From: Endoplasmic reticulum stress: major player in size-dependent inhibition of P-glycoprotein by silver nanoparticles in multidrug-resistant breast cancer cells75 nm AgNP treatment disrupts Pgp protein distribution between the plasma membrane and cytoplasm of MCF-7/KCR cells. a Relative mRNA and b protein levels of EDEM, a misfolded glycoprotein-binding protein in MCF-7/KCR cells treated with AgNPs. c Pgp protein levels determined from the plasma membrane (Na+/K+ ATPase-positive) and cytoplasmic fractions (GAPDH-positive) of control and 75 nm AgNP treated MCF-7/KCR cells (M-Plasma membrane; C-Cytoplasm)Back to article page