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Fig. 2 | Journal of Nanobiotechnology

Fig. 2

From: Inhibition of inflammatory response in human keratinocytes by magnetic nanoparticles functionalized with PBP10 peptide derived from the PIP2-binding site of human plasma gelsolin

Fig. 2

Biocompatibility of PBP10-based peptides and their magnetic derivatives. Metabolic activity of HaCaT cells treated with PBP10 (a), RhB-PBP10 (b) and RhB-PBP10-Cys (c) peptides in free form (black circles, squares and diamonds, respectively) and functionalized by gold- (+MNP@Au; grey symbols) and aminosilane-coated (+MNP@NH2; white symbols) magnetic nanoparticles for 24 h at doses ranging from 1 to 50 µg/mL. The viability of human keratinocytes incubated in the presence of bare MNP@Au (grey inverted triangles) and MNP@NH2 (white inverted triangles) is demonstrated in d. Results are presented as mean ± SD obtained from 3 experiments. ^Indicates statistically significant (p ≤ 0.05) activity of PBP10-containing nanosystems comparing to non-immobilized agents

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Journal of Nanobiotechnology

ISSN: 1477-3155

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