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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Inhibition of inflammatory response in human keratinocytes by magnetic nanoparticles functionalized with PBP10 peptide derived from the PIP2-binding site of human plasma gelsolin

Fig. 5

Inhibition of reactive oxygen species (ROS) generation in stimulated HaCaT cells. Level of reactive oxygen species formation in HaCaT cells stimulated with 1 µg/mL of LPS (a), LTA (b) or heat-inactivated suspension of E. coli RS218 (c) or S. aureus A1 (d) and treated simultaneously for 24 h with PBP10-based peptides and their magnetic derivatives at concentrations of 2 µg/mL (dark grey columns), 5 µg/mL (grey columns) and 10 µg/mL (light grey columns). Untreated stimulated control samples are indicated as 100%. Results are presented as mean ± SD obtained from 3 experiments. *Indicates statistically significant (p ≤ 0.05) activity of tested agents compared to untreated control samples, ^indicates statistical significance when comparing to MNP-based agents to non-immobilized peptides

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