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Fig. 8 | Journal of Nanobiotechnology

Fig. 8

From: Inhibition of inflammatory response in human keratinocytes by magnetic nanoparticles functionalized with PBP10 peptide derived from the PIP2-binding site of human plasma gelsolin

Fig. 8

Changes in nanomechanical properties of LPS-stimulated cells determined by AFM using an indentation depth value of 1 µm. Representative photograph of a single A549 cell probed using AFM working in force spectroscopy mode in liquid conditions (a). Summary of Young’s modulus analysis for cells treated with indicated agents at a dose of 5 µg/mL (b). Histograms presenting the distribution of force curves obtained from unstimulated cells, LPS-treated cells and endotoxin-stimulated cells incubated in the presence of PBP10 peptide and its magnetic derivatives are demonstrated in c. Results are presented as mean ± SD. * and ^Indicate statistically significant (p ≤ 0.05) activity of tested agents compared to untreated control samples and LPS-stimulated cells, respectively. #Indicates statistical significance when comparing MNP-based agents to the non-immobilized peptide

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Journal of Nanobiotechnology

ISSN: 1477-3155

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