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Table 3 IC50 (the concentration that is required for 50% inhibition of the metabolic activity of cells) and MHC10% values (minimum hemolytic concentration that caused 10% hemolysis of human red blood cells) assessed for tested peptides and their magnetic derivatives

From: Inhibition of inflammatory response in human keratinocytes by magnetic nanoparticles functionalized with PBP10 peptide derived from the PIP2-binding site of human plasma gelsolin

 

IC50 (µg/mL)

MHC10% (µg/mL)

PBP10

98.85 ± 6.67

6.02 ± 2.72

PBP10 + MNP@Au

169.22 ± 55.66

58.97 ± 39.31

PBP10 + MNP@NH2

94.17 ± 19.19

852.86 ± 607.82

RhB-PBP10

30.31 ± 5.30

51.12 ± 6.31

RhB-PBP10 + MNP@Au

33.91 ± 1.41

105.17 ± 67.30

RhB-PBP10 + MNP@NH2

34.42 ± 1.61

10.19 ± 1.18

RhB-PBP10-Cys

59.25 ± 11.60

72.92 ± 25.95

RhB-PBP10-Cys + MNP@Au

42.24 ± 5.76

94.76 ± 42.32

RhB-PBP10-Cys + MNP@NH2

32.76 ± 10.14

56.02 ± 2.75

MNP@Au

74.90 ± 35.28

511.17 ± 102.47

MNP@NH2

85.12 ± 22.56

707.39 ± 644.03

  1. Results are presented as the mean value calculated for 3 independent experiments ± SD
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Journal of Nanobiotechnology

ISSN: 1477-3155

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