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Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: Exosome-mediated targeted delivery of miR-210 for angiogenic therapy after cerebral ischemia in mice

Fig. 3

RGD-exo target the lesion region after intravenous administration. a Representative NIRF images of mouse brains that received MCAO/R and PBS, exosomes with miR-210 (Exo:miR-210), Scr-exo:miR-210, or RGD-exo:miR-210 administration. Brains were dissected 6 h after administration. b Quantitation of fluorescence intensity in the lesion region (intralesional) and matching nonlesion region (contralateral). The data are expressed as the mean ± SEM; *P < 0.05, and **P < 0.01, compared with the contralateral groups by two-way ANOVA. c The representative fluorescence distribution in organs (heart, lungs, liver, spleen, kidneys) dissected from mice that received MCAO/R and PBS, Exo:miR-210, Scr-exo:miR-210, or RGD-exo:miR-210 administration. Organs were dissected 6 h after administration. d Quantitation of fluorescence intensity in organs. The data are expressed as the mean ± SEM; *P < 0.05, **P < 0.01, and ***P < 0.001 by one-way ANOVA

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