Fig. 2From: Random and aligned electrospun PLGA nanofibers embedded in microfluidic chips for cancer cell isolation and integration with air foam technology for cell releasea Compositional analysis of the PLGA nanofibers through Raman spectroscopy, with bond stretching of C–O–C units at 873 cm−1, O–C at 1129 cm−1, O–C=O at 1453 cm−1, and C=O at 1760 cm−1. b, c Confocal Raman images of the random and aligned PLGA nanofiber arrays, according to the intensities of their signals at 1760 cm−1. d–f Schematic representations of the bioconjugation of biotinylated anti-EpCAM to PLGA nanofiber arrays for CTC isolation: d morphology of the nanofibers from SEM imaging; e EDC/NHS-mediated bonding of the biotin–(PEG)n to the surface of the PLGA nanofibers; f SA bonding to form biotinylated anti-EpCAM antibodies for capturing CTCsBack to article page