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Fig. 2 | Journal of Nanobiotechnology

Fig. 2

From: Random and aligned electrospun PLGA nanofibers embedded in microfluidic chips for cancer cell isolation and integration with air foam technology for cell release

Fig. 2

a Compositional analysis of the PLGA nanofibers through Raman spectroscopy, with bond stretching of C–O–C units at 873 cm−1, O–C at 1129 cm−1, O–C=O at 1453 cm−1, and C=O at 1760 cm−1. b, c Confocal Raman images of the random and aligned PLGA nanofiber arrays, according to the intensities of their signals at 1760 cm−1. d–f Schematic representations of the bioconjugation of biotinylated anti-EpCAM to PLGA nanofiber arrays for CTC isolation: d morphology of the nanofibers from SEM imaging; e EDC/NHS-mediated bonding of the biotin–(PEG)n to the surface of the PLGA nanofibers; f SA bonding to form biotinylated anti-EpCAM antibodies for capturing CTCs

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