Nanocomposites as biomolecules delivery agents in nanomedicine

Bamburowicz-Klimkowska, Magdalena; Poplawska, Magdalena; Grudzinski, Ireneusz P.

doi:10.1186/s12951-019-0479-x

Table 2 Examples of aptamers targeted nanosystems

From: Nanocomposites as biomolecules delivery agents in nanomedicine

Type of nanomaterial	Aptamer	Cargo	Justification	Efficacy test	References
Carboxyl-modified, streptavidin-coated magnetic beads	Extracellular peptide epitope of CD123 (ZW25)	DOX	Targeted chemotherapy	AML cells BALB/c mice	[139]
PEG	Integrin α6β4 (IDA), eIF4E (AS1411), MNK1 (apMNK2F)	Drug-free	Targeted chemotherapy	PC-3 cells, 4T1 cells BALB/c mice	[140]
Aptamer-based DNA diamond nanostructure	MUC1 ATP	Epirubicin	Targeted chemotherapy	C26 cells MCF-7 cells BALB/c mice	[141]
DNA nanoflowers	Sgc8 MUC1	Fluorescein, cyanine3 6-carboxy-X-rhodamine	Fluorescence imaging	MCF-7 cells	[142]
Gold nanorods	MUC1	DOX	Targeted chemo- and photothermal therapy	MCF-7 cells	[143]
PEG/gold nanorods	Ramos ATP	DOX	Targeted chemotherapy, fluorescence imaging	Ramos cells Ramos tumor-bearing nude mice	[144]
PEG-MnO	AS1411		MRI contrast agent	786–0 renal carcinoma, EA.hy926 cells BALB/c mice	[145]
GO	Sgc8c ATP	Drug-free	Targeted chemotherapy	Molt-4 cells	[146]
GO	MUC1 Vimentin (NAS-24)		Targeting apoptosis induction	MDA-MB-231 cells MCF-7 cells	[147]
GO	MUC1 Cytochrome c		Targeting apoptosis induction	MDA-MB-231 cells MCF-7 cells	[147]
GO/AuNP	MUC1	DOX	Targeted chemo- and photothermal therapy	MCF-7 cells, A549 cells	[148]
Mesoporous carbon NPs, polyacrylic acid, PEI	MUC1	DOX	Targeted chemotherapy	MCF-7 cells, A549 cells	[149]
MNPs	Sgc8c	DOX	Targeted chemotherapy	CEM, Ramos xenografted tumor mice	[150]
SPION (Au)	MUC1		Photothermal therapy MRI	HT-29 cells	[151]
Myristylated chitosan	Androgen-sensitive human prostate adenocarcinoma cells aptamer	DOX	Targeted chemotherapy	LNCaP cells	[152]
PLGA/chitosan	MUC1	Epirubicin	Targeted chemotherapy	MCF-7 cells BALB/c mice	[153]
PLGA/PEG	Platelatet-derived growth factor receptor β	PI3K-mTOR inhibitor	Deliver a multifunctional nanosystem to the brain	U87MG cells orthotopic cancer-bearing mice	[154]
PLGA/PEG	(HCC)-specific (TLS11a)	DOX	Targeted chemotherapy	HCC mouse liver cells	[155]
Liposomes/chitosan	Anti-EGFR	Erlotinib	Targeting apoptosis induction	H1975 cells PC-9 cells	[156]
QDs/Se	AS1411		Targeting apoptosis induction, fluorescence imaging	U87 cells U251 cells HeLa cells A375 cells Siha cells MCF-7 cells EJ cells	[157]
	ssDNA–GMT-3	DOX	Targeted chemotherapy	A-172 cells, MCF-7 cells	[158]

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