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Table 4 Examples of RGD-targeted nanovehicles

From: Nanocomposites as biomolecules delivery agents in nanomedicine

Type of nanomaterial

Targeting ligand

Justification

Efficacy test

References

GO/Pluronic F127

FA

Cyclic RGD peptide

Photothermal therapy

KB cells

[192]

GO nanosheets/Poloxamer 188

Cyclic arginine–glycine–aspartic acid–tyrosine–lysine pentapeptides

Combretastain chemotherapy

HeLa cells

[193]

Graphene QDs

RGD peptide

DOX

U251 glioma cells

[194]

PEG/PLGA micelles

Stapled RGD

Paclitaxel chemotherapy

BBB penetration

U87 cells

HUVEC cells

BALB/c nude mice

[195]

Lipid-coated PEG/PLGA

RDG peptide

Sorafenib and quercetin chemotherapy

HCC cells

BALB/c nude mice

[196]

PAMAM

IL-6 antibody RGD peptide

DOX chemotherapy

HeLa cells

[118]

PEI-cyclodextrin-poly γ-glutamic acid

Gamma-glutamyl transpeptidase

RDG peptide

monensin

Targeting extrinsic apoptosis via TRAIL signalling

HCT8/ADR cells

HCT8/ADR tumour-bearing BALB/c nude mice

[197]

PEG/poly(ε-caprolactone) micelles

Cyclic RGD peptide

DOX chemotherapy

U87MG cells

Nude mice

[29]

Se/chitosan

RGD peptide

DOX chemotherapy

HUVEC cells

C57BL/6 mice

[198]