Fig. 3From: Intracisternal delivery of PEG-coated gold nanoparticles results in high brain penetrance and long-lasting stabilityLongitudinal distribution of AuNPs in ICM-injected mice. a FLI imaging of a single animal receiving ICM injection of Cy5.5-AuNPs. Pictures were recorded at different time points (1 h, 1, 2, 3, 4, 7, 10, 16 and 25 days after the injection). FLI levels recorded in a control animal receiving ICM injection of unconjugated Cy5.5 are shown in b. The epi-fluorescence scale used in both experiments is shown on the right side of the panel. Plots in c, d show quantifications of FR levels (mean ± S.D.) in mice receiving Cy5.5-AuNPs (c) as well as in mice receiving soluble Cy5.5 (d), (n = 3 for each group)Back to article page