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Fig. 1 | Journal of Nanobiotechnology

Fig. 1

From: Alteration in the mRNA expression of genes associated with gastrointestinal permeability and ileal TNF-α secretion due to the exposure of silver nanoparticles in Sprague–Dawley rats

Fig. 1

Six major types of cell junctions in the intestinal epithelium. (1) Tight junctions play a key role in sealing cells together and creating a barrier that is crucial in controlling paracellular transport. (2) Adherens junctions interact with the actin cytoskeleton and cadherins to support cell–cell adhesion. (3) Similarly, desmosomes adhere neighboring cells with cadherin proteins and intermediate filaments. (4) Gap junctions serve as cytoplasmic bridges between cells and are essential in communication and movement of small molecules. (5) Focal adhesions interact with integrins and actin filaments to promote adhesion between cells and the extra cellular matrix. (6) Finally, hemidesmosomes are also associated with integrins, but form connections with intermediate filaments in order to anchor cells to the extra cellular matrix. All six of these major junctions are central in epithelial adhesion, communication, and notably, intestinal permeability

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Journal of Nanobiotechnology

ISSN: 1477-3155

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