Skip to main content
Fig. 1 | Journal of Nanobiotechnology

Fig. 1

From: Redox/NIR dual-responsive MoS2 for synergetic chemo-photothermal therapy of cancer

Fig. 1

Synthesis and characterization of MoS2–SS–HA nanosheets. a Schematic of the synthesis of MoS2–SS–HA as a carrier capable of achieving targeted delivery of CPT and controlled drug release under dual stimuli for synergetic chemo-photothermal cancer therapy. (i, ii) Chemical exfoliation of MoS2 crystals to single-layered MoS2 nanosheets and synthesis of sulfhydrylated HA, (iii) conjugation of MoS2 with HA via a disulfide linkage, (iv) the CPT loading process, (v) intravenous administration of MoS2–SS–HA–CPT and efficient accumulation of the nanosheets at the tumor site based on passive and active targeting, and (vi) cellular uptake of HA-grafted MoS2 nanosheets, rapid intracellular drug release, and synergetic chemo-photothermal therapy: (1) cellular uptake of MoS2–SS–HA–CPT via HA-receptor-mediated endocytosis; (2) MoS2-based generated hyperthermia upon NIR irradiation; (3) and (4) redox- and NIR-triggered drug release; and (5) and (6) hyperthermia-induced photothermal therapy and CPT-mediated chemotherapy. b FT-IR spectra of MoS2 before and after HA coating. c AFM images of MoS2 and MoS2–SS–HA. d Stability of MoS2 and MoS2–SS–HA suspensions in water, PBS, and cell medium for 1 week

Back to article page