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Fig. 7 | Journal of Nanobiotechnology

Fig. 7

From: Susceptibility of microbial cells to the modified PIP2-binding sequence of gelsolin anchored on the surface of magnetic nanoparticles

Fig. 7

Magnetic nanoparticles enhance the uptake of PBP10 peptides by Candida cells and increase candidacidal properties. Optical images and atomic force microscopy topography of Candida albicans cells treated by tested peptides as free and immobilized molecules. C. albicans cells treated by unlabeled PBP10, Cys-PBP10-RhB and PBP10-RhB derivatives (A, C, E, respectively): a, e—control; b, f-treated by peptide alone; c, d and g, h—treated by agent immobilized on gold or aminosilane coated MNPs, respectively (e–h vertical deflection mode). B indicates hypothesized mode of action proposed for tested PBP10 derivatives immobilized on MNPs. D (Cys-PBP10-RhB) and F (PBP10-RhB) show internalization of peptide into Candida albicans cells treated by PBP10 peptides in free and immobilized form; small panels show merged photography of C. albicans cells: a—treated by PBP10 peptide; b, c—treated by PBP10 peptide immobilized on gold modified and aminosilane coated MNPs. Statistical significance for the samples treated by peptides in immobilized form compared to the peptide in free form is marked by (*)

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