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Table 12 Antioxidant activity

From: Synthesis and biomedical applications of nanoceria, a redox active nanoparticle

S. no Particle size/morphology Cell type Observation References
1. 3–5 nm Adult rat spinal cord cells A significant neuroprotective effect on adult rat spinal cord neurons were observed [100]
2. 4 nm Cardiomyocytes and human dermal fibroblasts Dextran-coated nanoceria protects healthy cells against hydrogen peroxide-induced oxidative stress [35]
3. 3–5 nm Human colon cells (CRL 1541) Nanoceria reduce ROS levels and protect healthy human colon cells from radiation-induced damage [134]
4. 5–8 nm Cardiac progenitor cells (CPCs) Nanoceria controls the oxidative stress in CPCs [139]
5. 20 nm/cubic Endothelial cells CeO2 reduces intracellular free radicals in endothelial cells and thus helps in controlling cardiovascular diseases [135]
6. 5–80 nm/cubic Neuron-like PC12 cells CeO2 scavenged ROS and exerted neuroprotection via regulating genes involved in cellular defense [140]
7. < 25 nm/cubic and triangular A human epithelial lung cell line, BEAS-2B Pre-treatment of CeO2 significantly reduced the intracellular production of ROS induced by KBrO3 [136]
8. 5 nm/spherical NIH3T3 cells Levan coated CeO2 protected NIH3T3 cells against H2O2-induced oxidative stress [137]
9. < 5 nm Neuron-like SH-SY5Y cells Showing beneficial effects in terms of neurite development and alignment [141]
10. 30 nm Brain tissue samples of rats CeO2 protected against Paraquat-induced neuronal oxidative stress and apoptosis [138]