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Table 13 Anticancer activity

From: Synthesis and biomedical applications of nanoceria, a redox active nanoparticle

S. no Size (nm) Cell line Observation References
1. 20 Human lung cancer cells (A549 cells) Free radicals were generated on the exposure of 3.5 to 23.3 µg/mL nanoceria which causes oxidative stress and cytotoxic effect in the cancer cells [142]
2. 100–200 Human prostate cancer cell line (PC-3) Nanoceria showed cytotoxicity in prostate cancer cells but was non-toxic in normal cells at the conc. of 5 mg/mL [48]
3. 3–5 Ovarian cancer cells (A2780) and A2780 xenograft murine model Conc. between 25 and 50 µM showed an anti-angiogenic effect in ovarian cancer cells and reduced tumor size in vivo [75]
4. 3–5 Human colon cancer cells (HCT 15) Conc. between 10 and 100 µM resulted in a significant reduction of cell viability via increasing ROS levels [144]
5. < 25 Human neuroblastoma cell line (IMR32) Nanoceria exposure generated ROS that induced oxidative stress, which leads to cytotoxicity and genotoxicity in IMR32 cells at higher conc. (> 100 µg/mL) [145]
6. 10 Ovarian cancer cells (A2780) and A2780 xenograft murine model Folic acid tagged nanoceria showed significant inhibition in viable cells in A2780 cells within the conc. range 10–100 μM, and reduced tumor size in vivo [143]
7. 30 Fibrosarcoma cell line (WEHI164) Conc. of nanoceria ≥ 15.63 µg/mL showed toxicity effects in cancer cells via increasing ROS levels and apoptosis [146]