Table 13 Anticancer activity
From: Synthesis and biomedical applications of nanoceria, a redox active nanoparticle
S. no | Size (nm) | Cell line | Observation | References |
|---|---|---|---|---|
1. | 20 | Human lung cancer cells (A549 cells) | Free radicals were generated on the exposure of 3.5 to 23.3 µg/mL nanoceria which causes oxidative stress and cytotoxic effect in the cancer cells | [142] |
2. | 100–200 | Human prostate cancer cell line (PC-3) | Nanoceria showed cytotoxicity in prostate cancer cells but was non-toxic in normal cells at the conc. of 5 mg/mL | [48] |
3. | 3–5 | Ovarian cancer cells (A2780) and A2780 xenograft murine model | Conc. between 25 and 50 µM showed an anti-angiogenic effect in ovarian cancer cells and reduced tumor size in vivo | [75] |
4. | 3–5 | Human colon cancer cells (HCT 15) | Conc. between 10 and 100 µM resulted in a significant reduction of cell viability via increasing ROS levels | [144] |
5. | < 25 | Human neuroblastoma cell line (IMR32) | Nanoceria exposure generated ROS that induced oxidative stress, which leads to cytotoxicity and genotoxicity in IMR32 cells at higher conc. (> 100 µg/mL) | [145] |
6. | 10 | Ovarian cancer cells (A2780) and A2780 xenograft murine model | Folic acid tagged nanoceria showed significant inhibition in viable cells in A2780 cells within the conc. range 10–100 μM, and reduced tumor size in vivo | [143] |
7. | 30 | Fibrosarcoma cell line (WEHI164) | Conc. of nanoceria ≥ 15.63 µg/mL showed toxicity effects in cancer cells via increasing ROS levels and apoptosis | [146] |