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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Exosome-mimetic nanoplatforms for targeted cancer drug delivery

Fig. 5

In vivo biodistribution of natural exosomes and F-EMNs loaded with miR145-Cy5. a Representative image ex vivo (left) and quantification of the Cy5 emission (right) of the lung (tumor) after treatment with natural exosomes or F-EMNs. The luminescence signal (up) and Cy5 fluorescence (down) of the same tumor were shown. b Representative confocal microscopy images of lung tumor cryosections stained with DAPI (blue) and ki67 (green) for analyzing the miR145-Cy5 intracellular uptake in vivo (red) in the metastatic cells after the same treatments indicated in (a). The arrows label the areas of miR145-Cy5 accumulation and the scale bar represents 10 μm. c Representative image ex vivo (left) and quantification of the Cy5 emission (right) of the indicated organs. The scale bars (a, c) represent the luciferase intensity (left) and Cy5-fluorescence (right, arbitrary units). The data in graphs (ac) denote the mean values ± SEM from n = 5 mice per condition and Cy5 fluorescence signal was normalized to the background obtained from tumors of mice control. *p < 0.05. Data without statistical significance were not indicated

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