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Fig. 11 | Journal of Nanobiotechnology

Fig. 11

From: Improving the anticancer effect of afatinib and microRNA by using lipid polymeric nanoparticles conjugated with dual pH-responsive and targeting peptides

Fig. 11

Effect of various treatments on migration, MDR and other pathways in Caco-2 cells. a Migration assay was evaluated on Transwell inserts. After different treatments, the cells were stained with 0.2% crystal violet and observed by microscope. Purple dots were the migrated cells across the Transwell inserts. b Relative percentages of migrated cells compared to CTR. Data are shown as mean ± SD, n = 3. *P < 0.05: compared with CTR, †P < 0.05: compared with Afa, ‡P < 0.05: compared with Afa/LPN, ¶P < 0.05: compared with Afa/LPN-HR, and §P < 0.05: compared with miR-139/LPN-HR. c, d Protein expressions of c EMT/MDR and d Rac1/Ras/Erk/MAPK/COX-2 pathways were evaluated after various treatments on Caco-2 cells for 72 h by western blot. The experiments were performed in triplicate with the similar results

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