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Fig. 2 | Journal of Nanobiotechnology

Fig. 2

From: Magnetic targeting of adoptively transferred tumour-specific nanoparticle-loaded CD8+ T cells does not improve their tumour infiltration in a mouse model of cancer but promotes the retention of these cells in tumour-draining lymph nodes

Fig. 2

APS-MNP subcellular localisation in OT-I CD8+ T cells. a Representative images acquired using confocal microscopy of the OT-I CD8+ T cells after treatment with APS-MNPs (cell membrane (red), MNPs (grey), and core (blue)) (scale = 10 μm). The orthogonal projections were composed using the ImageJ software. b Prussian blue staining and neutral red counterstain of OT-I CD8+ T cells after association with the MNPs (scale = 10 μm). c Representative images obtained by TEM of OT-I CD8+ T cells after treatment with APS-MNPs. The upper panels offer an overall view of the cell, while the lower panels show cellular regions in greater detail to better illustrate the interactions between APS-MNPs and the cell membrane. d TEM images at greater magnifications showing further interaction between the APS-MNPs and the cell surface. The arrows indicate the presence of APS-MNPs associated with the cells

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