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Fig. 8 | Journal of Nanobiotechnology

Fig. 8

From: A ROS-responsive polymeric prodrug nanosystem with self-amplified drug release for PSMA (−) prostate cancer specific therapy

Fig. 8

In vivo antitumor effects of different drug formulations. a Relative tumor volumes of PC-3 tumor-bearing mice after treatments with saline, DOX, AD-NPs, TD-NPs, and ATD-NPs (equivalent of 5 mg/kg DOX) for 21 days. b Extracted tumor weights. c Tumor inhibition rate. d Mice body weight. e Survival rates of mice after injected different formulations. f The alanine aminotransferase (ALT, 10 U/L), aspartate transaminase (AST, 10 U/L), and blood urea nitrogen (BUN, 100 µmol/L) in the serum of PC-3 tumor-bearing mice. g Images of H&E staining of tumor section acquired at 20× objective. Error bars showed as mean ± SD (n = 10), **p < 0.01, ***p < 0.001

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