Fig. 5
Biodistribution and antitumor efficacy of Co-A15-Exo in vivo. A In vivo imaging of Cy5-Cho-miRNA loaded Exo in MDA-MB-231 tumor-bearing nude mice after tail vein injection of free Cy5-Cho-miRNA, Exo-Cy5-Cho-miRNA, or A15-Exo-Cy5-Cho-miRNA. (a) Images were taken 1 h, 2 h, 4 h, or 8 h after the administration of free Cy5-Cho-miRNA, Exo-Cy5-Cho-miRNA, or A15-Exo-Cy5-Cho-miRNA. (b) Ex vivo imaging of tumor and organs collected at the end of the experiment (8 h post-injection). B Tumor growth curves of mice receiving different therapeutic regimens (n = 5, mean ± SD). C Body weight changes during treatment. Data are expressed as the mean ± SD (n = 5). **p < 0.01, vs. PBS. D The weights of the excised tumor tissues from all groups. Data are expressed as the mean ± SD (n = 5). *p < 0.05 and **p < 0.01 when compared with the indicated groups. E Survival rate of MDA-MB-231 tumor-bearing BALB/c nude mice