Fig. 1
From: A near infrared light-triggerable modular formulation for the delivery of small biomolecules
a Schematic representation of the preparation of RAn-CB[6] @AuNR formulation for the intracellular delivery of RA after NIR activation. b Scheme for the synthesis of CB[6] HA conjugate. HA (8–15 kDa) was reacted with 3,3´-dithiobis(propanoic hydrazine) (DTP) in the presence of 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide (EDC) and then dithiothreitol (DTT) to obtain 70% thiolated HA (HS-HA). Next, HS-HA was reacted with (allyloxy)12CB[6] in DMSO for 3 h under UV light to obtain CB[6] HA (DS = 8 ± 1 mol %)