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Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: A near infrared light-triggerable modular formulation for the delivery of small biomolecules

Fig. 3

Release profile of IA and RA from CB[6] @AuNRs. a Schematic representation of the cargo release after irradiation the AuNRs with near-infrared light (780 nm, 2 W/cm2). b Representative fluorescence spectra of IA complexed with CB[6] @AuNR (50 µg/mL) at different temperatures. c Representative fluorescence spectra of IA complexed in CB[6] @AuNR (50 µg/mL) upon irradiation with NIR light for 2 min or after adding a competitive ligand (spermine (SPM), 0.5 mM)) to displace IA. d Chemical structures of the RA conjugates. e RA1-CB[6] @AuNRs (10 µg/mL) were irradiated by NIR laser, the suspension centrifuged two times (2SN), the supernatant collected and the absorbance measured. At the end, the formulation was suspended in water and a competitive ligand (SPM 0.5 mM) was added to displace RA1 from AuNRs (3SN-SPM). f Quantification of RA1 released after irradiation with NIR light. After irradiation, the suspension was immediately centrifuged, the supernatant was collected (3SN-NIR) and the amount of RA1 was determined using a calibration curve of RA1. g Percentage of RA1, RA2 and RA3 release upon irradiation the CB[6] @AuNRs (10 µg/mL) for different times. Results are expressed as average ± SEM (n = 3)

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