Scheme 1

a Schematic illustration of the preparation of PC₁₀A/DOX/HAuNS nanoparticles and PC₁₀A/DOX/HAuNS hydrogel through self-assemble layer-by-layer and “dissolving” the PC₁₀A/DOX/HAuNS nanoparticles in the PC₁₀A hydrogel, respectively; b PC₁₀A/DOX/HAuNS hydrogel with sequential drug release were utilized for sustained chemotherapy and photothermal therapy in vivo