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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: pH and redox dual-responsive nanoparticles based on disulfide-containing poly(β-amino ester) for combining chemotherapy and COX-2 inhibitor to overcome drug resistance in breast cancer

Fig. 4

Cellular uptakes and intracellular locations of HPPDC nanoparticles. Confocal images of MCF-7 (a) and MCF-7/ADR cells (c) after incubation with free DOX, HPPD and HPPDC nanoparticles for 8 and 24 h. Flow cytometry analysis of MCF-7 (b) and MCF-7/ADR cells (d) after 24 h incubation with free DOX, HPPD and HPPDC nanoparticles. Flow cytometry analysis of MCF-7/ADR cells after 36 h (e) and 48 h (f) incubation with free DOX, HPPD and HPPDC nanoparticles. g The comparison of intracellular fluorescence intensities of different groups treated MCF-7/ADR cells. DOX concentration was 0.5 μg/mL for MCF-7 cells and 5 μg/mL for MCF-7/ADR cells. Cell nuclei were stained with DAPI showing a blue fluorescence. ** indicates P < 0.01 between two treatment groups

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