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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: pH and redox dual-responsive nanoparticles based on disulfide-containing poly(β-amino ester) for combining chemotherapy and COX-2 inhibitor to overcome drug resistance in breast cancer

Fig. 5

In vitro synergistic inhibitory effects of HPPDC nanoparticles on drug resistant breast cancer. Cytotoxicities of free DOX, DOX/CXB mixture, HPPD and HPPDC nanoparticles in MCF-7 (a) and MCF-7/ADR cells (b) at 72 h after incubation. Apoptosis analysis of MCF-7 (c) and MCF-7/ADR cells (d) at 24 h after various treatments (Q1: dead cells; Q2: late apoptotic cells; Q3: early apoptotic cells; Q4: living cells). e Relative mRNA expressions of MDR1 in MCF-7/ADR cells at 24 h after various treatments. GAPDH was used as an internal control. f Western blotting analyses of COX-2 and P-gp expressions in MCF-7/ADR cells at 24 h after various treatments. * and ** separately indicate P < 0.05 and < 0.01 compared to the control; # and ## separately indicate P < 0.05 and < 0.01 for comparison between two treatment groups

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