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Fig. 2 | Journal of Nanobiotechnology

Fig. 2

From: Cerium oxide nanoparticles improve liver regeneration after acetaminophen-induced liver injury and partial hepatectomy in rats

Fig. 2

CeO2NPs treatment increased liver regeneration and cell proliferation after PHx. a Body weights of control rats without treatment and rats that received vehicle or CeO2NPs before PHx (n = 8). b Hepatic regenerative index at day 6 after PHx (n = 8, p < 0.05). c Blood levels of ALT (*p < 0.01), AST (*p < 0.05) and LDH (*p < 0.05) in vehicle or CeO2NPs-treated rats after 3 h post-PHx (n = 8; mean ± SEM). d Representative immunostaining for the Ki-67 antigen in liver histological sections of rats treated with either vehicle or CeO2NPs at different time points (t = 0 h, 24 h, 48 h, 7 days). Merged images show co-localization of Ki-67 (green) and nuclear DNA (DAPI, blue). Original magnification ×200 (n = 8 for each group and treatment). On the bottom, percentage quantification of positive Ki-67 liver cells for each time point and treatment (n = 8; mean ± SEM; *p < 0.05 compared with vehicle at the same time points)

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