Fig. 3
The intracellular Ca2+ concentration under different treatment conditions. a Intracellular Ca2+ concentration in control(red), MW (blue), MW + NP (orange) and MW + NP* (green). b Intracellular Ca2+ concentration in control(red), DOX (blue), MW (orange) and MW + DOX(green). The concentration of Ca2+ in DOX + MW group was highest. c The four histograms represented the mean fluorescence intensity in the control, DOX, MW and DOX + MW group. d The four histograms represented the mean fluorescence intensity in the control, MW, MW + NP and MW + NP* group. Significant differences were found in all experimental group when compared with the control group. NP NaCl@PLGA nanoparticles, NP* NaCl–DOX@PLGA nanoparticles, **P < 0.01