Scheme 1
Schematic illustration of the multifunctional NaCl–DOX@PLGA nanoplatforms under mild MW irradiation. The thermal effect of the as-made nanoparticles could rise the temperature of the tumor and enhance DOX release. With the pretreatment of DOX and MW irradiation, intracellular Ca2+ concentration substantially increased, inducing more apoptosis. Hence, the multifunctional nanoplatform could realize effective tumor killing in a safe and controlled manner