Fig. 6From: Ultrasmall nanostructured drug based pH-sensitive liposome for effective treatment of drug-resistant tumorIn vivo anti-efflux, cell nuclear distribution and biosafety studies. a CLSM images of tumor tissues harvested from DOX, DOX@liposome or LNSD treated MCF-7/ADR tumor-bearing mice at 24 h post injection (red FLR: DOX; blue FLR: DAPI), scale bar: 100 μm. b Co-localization ratio of DOX (red FLR) and cell nuclear (blue FLR) in tumor tissues harvested from DOX, DOX@liposome or LNSD treated MCF-7/ADR tumor-bearing mice (n = 20). c Representative H&E staining images of liver tissue received saline or LNSD treatments, scale bar: 200 μm. d ALT, AST, BUN and CR in serum were detected in different treatments on day 14 (n = 5). Data presented are means ± SD. *p < 0.05***p < 0.01Back to article page