Fig. 4From: iRGD-guided tamoxifen polymersomes inhibit estrogen receptor transcriptional activity and decrease the number of breast cancer cells with self-renewing capacityiRGD-PS-Tam inhibits ER transcriptional activity. MCF7 (a) and T47D (b) cells were plated in 48 well plates and transiently transfected with PTK-ERE-Luc and pTK Renilla reporter constructs. The cells were subsequently treated for 24 h with estradiol (E2), Tam, iRGD-PS-Tam, E2 + Tam and E2 + iRGD-PS-Tam. Data are represented as mean ± SD, N = 3, one-way Anova followed by Bonferroni–Sidak’s multiple comparisons was used to compare groups *p < 0.05; ***p < 0.001Back to article page