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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: iRGD-guided tamoxifen polymersomes inhibit estrogen receptor transcriptional activity and decrease the number of breast cancer cells with self-renewing capacity

Fig. 5

iRGD-PS-Tam exposure reduces the number of tumorspheres. MCF7 and T47D cells were pre-treated for 48 h with vehicle (control), Tam, iRGD-PS-TAM or iRGD + Tam and then plated in non-adherent plates under tumorsphere culture conditions as explained in materials and methods. a Representative images of tumorspheres of MCF-7 and T47D generated from pre-treated cells as explained. Scale bars: 200 μm. b Tumorsphere count per well is shown for MCF7 and T47D cells. Data are represented as mean ± SD, N = 3, one-way Anova followed by Bonferroni–Sidak’s multiple comparisons was used to compare groups *p < 0.05; ***p < 0.001

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