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Fig. 8 | Journal of Nanobiotechnology

Fig. 8

From: iRGD-guided tamoxifen polymersomes inhibit estrogen receptor transcriptional activity and decrease the number of breast cancer cells with self-renewing capacity

Fig. 8

Graphical abstract. Tamoxifen (Tam) loaded, iRGD functionalized PEG-PCL polymersomes (iRGD-PS-Tam) were developed for the treatment of estrogen receptor (ER) positive breast cancer. Results show that iRGD-PS-Tam were effective in inhibiting cell proliferation and resensitizing cells cultured on fibronectin (FN) to Tam. Additionally, iRGD-PS-Tam reduced the number of cells with self-renewing capacity, a hallmark of cancer stem cells. Mechanistically, treatment of cells with iRGD-PS-TAM resulted in inhibition of ER’s transcriptional activity. Finally, in vivo studies showed selective accumulation at the tumor site

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