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Table 1 The actions and limitations of WAT browning agents

From: Nanotechnology advances towards development of targeted-treatment for obesity

Browning agents Actions Limitations Current application Refs
Dibenzazepine γ-Secretase inhibitor
Inhibit Notch signaling
Act in the liver to improve systemic metabolism
Solubility
Non-specificity
Anti-depressant [17]
Resveratrol Sirtuin activator Solubility
Stability
Metabolic transformation
Less bioavailability
High metabolism in humans
CVDs [23, 66]
Rosiglitazone PPAR gamma activator Hydrophobic
Solubility
T2D [12]