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Table 1 The actions and limitations of WAT browning agents

From: Nanotechnology advances towards development of targeted-treatment for obesity

Browning agents

Actions

Limitations

Current application

Refs

Dibenzazepine

γ-Secretase inhibitor

Inhibit Notch signaling

Act in the liver to improve systemic metabolism

Solubility

Non-specificity

Anti-depressant

[17]

Resveratrol

Sirtuin activator

Solubility

Stability

Metabolic transformation

Less bioavailability

High metabolism in humans

CVDs

[23, 66]

Rosiglitazone

PPAR gamma activator

Hydrophobic

Solubility

T2D

[12]