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Table 3 Synthetic biodegradable polymers commonly used in tendon/ligament regeneration

From: Biodegradable polymer nanocomposites for ligament/tendon tissue engineering

Synthetic BiomaterialAdvantagesDisadvantages
PLLASlow degradation rate (10 months to 4 years) [33], better cell adhesion than PGA or PLGA. Easily manufactured [7]Acidic degradation [7]
PCLEasily manufactured; FDA approved material [7]; (over 3 years in vivo) [67]Very slow degradation rate [7]
PGAEasily manufactured; FDA approved material [7]Rapid (6–12 months) [68] and acidic degradation [7]; lack of signaling molecules [61]
PLGAHalf-life of 1.5 months [68]; Degradation rate can be tailored by changing the ratio of PLA:PGA. Easily manufactured [7]Acidic degradation [7]
PLCLProperties can be tailored by changing the ratio of PLA:PCL. Good biocompatibility and mechanical properties; easily manufactured [69]Excessively elastic for tendon regeneration [69]