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Fig. 6 | Journal of Nanobiotechnology

Fig. 6

From: Incorporation of drug efflux inhibitor and chemotherapeutic agent into an inorganic/organic platform for the effective treatment of multidrug resistant breast cancer

Fig. 6

NV@CaP-RGD effectively inhibited the expression of drug efflux proteins and decreased the intracellular concentration of ATP in MDR breast cancer cells. Western blotting images of the expression of efflux pump proteins in a MCF7 cells and b MCF7/MDR cells. Western blotting analysis showed that the expression of efflux pump proteins (P-gp, MRP and BCRP proteins) significantly decreased in the NV@CaP-RGD group. c, d The amount of ATP in MCF7 and MCF/MDR tumor cells treated with various concentrations of RGD-NPs and NPs. As the concentration increased, the ATP concentration decreased substantially (***P < 0.001 compared with the nontreated control group). Due to insufficient energy, the function of the efflux pump proteins was significantly inhibited

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Journal of Nanobiotechnology

ISSN: 1477-3155

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