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Table 1 Effect of Fe3O4@SiO2–NH2 nanoparticle administration on blood biochemical indexes

From: Size-dependent tissue-specific biological effects of core–shell structured Fe3O4@SiO2–NH2 nanoparticles

Indexes

C6a

S6

M6

L6

C48

S48

M48

L48

TP (g/L)

54.96 ± 2.18b

55.44 ± 2.29

57.56 ± 3.38

57.62 ± 1.60

55.53 ± 1.98

56.71 ± 2.36

55.04 ± 2.26

56.30 ± 3.59

Alb (g/L)

30.66 ± 1.01

30.54 ± 0.74

30.98 ± 1.08

30.74 ± 0.35

30.95 ± 0.75

30.86 ± 0.88

29.81 ± 0.75*

30.51 ± 1.25

Glo (g/L)

24.30 ± 1.24

24.90 ± 1.69

26.58 ± 2.37

26.88 ± 1.35*

24.58 ± 1.43

25.85 ± 1.62

25.23 ± 1.63

25.79 ± 2.36

Alb/Glo

1.26 ± 0.03

1.23 ± 0.06

1.17 ± 0.07*

1.15 ± 0.05**

1.26 ± 0.06

1.2 ± 0.05

1.19 ± 0.05*

1.19 ± 0.06

Tbil (μmol/L)

2.14 ± 0.23

2.36 ± 0.15

2.06 ± 0.25

2.24 ± 0.45

2.22 ± 0.19

2.40 ± 0.21

2.39 ± 0.16

2.39 ± 0.21

Dbil (μmol/L)

0.80 ± 0.07

0.72 ± 0.08

0.78 ± 0.11

0.78 ± 0.08

0.82 ± 0.08

0.86 ± 0.09

0.85 ± 0.09

0.88 ± 0.10

Ibil (μmol/L)

1.34 ± 0.18

1.64 ± 0.09*

1.28 ± 0.25

1.46 ± 0.40

1.40 ± 0.15

1.54 ± 0.14

1.54 ± 0.09

1.51 ± 0.12

ALT (U/L)

56.20 ± 5.81

51.20 ± 5.36

65.80 ± 8.41

76.80 ± 33.07

49.17 ± 8.86

46.88 ± 6.33

48.13 ± 9.72

45.88 ± 3.40

AST (U/L)

204.40 ± 36.05

195.20 ± 33.52

202.60 ± 18.94

195.60 ± 60.80

159.50 ± 45.05

139.25 ± 33.78

135.25 ± 26.76

133.75 ± 23.87

AST/ALT

3.64 ± 0.51

3.88 ± 0.93

3.10 ± 0.35

2.66 ± 0.40*

3.23 ± 0.59

2.96 ± 0.47

2.85 ± 0.45

2.91 ± 0.46

GGT (U/L)

0.64 ± 0.49

0.28 ± 0.40

0.28 ± 0.40

0.46 ± 0.49

1.00 ± 0.00

0.55 ± 0.48

0.89 ± 0.32

1.00 ± 0.00

ALP (U/L)

414.00 ± 119.44

338.00 ± 38.86

353.60 ± 20.79

345.20 ± 34.54

363.33 ± 77.29

320.5 ± 68.26

308.75 ± 61.68

291.38 ± 46.15

TG (mmol/L)

1.53 ± 0.35

1.49 ± 0.40

1.73 ± 0.65

2.23 ± 1.88

1.77 ± 0.62

1.76 ± 0.65

1.16 ± 0.33

0.91 ± 0.25**

TC (mmol/L)

2.49 ± 0.36

2.25 ± 0.42

2.54 ± 0.43

3.06 ± 0.35*

2.19 ± 0.18

2.42 ± 0.28

2.24 ± 0.25

2.48 ± 0.22**

HDL-C (mmol/L)

0.78 ± 0.10

0.68 ± 0.14

0.73 ± 0.09

0.80 ± 0.22

0.71 ± 0.07

0.75 ± 0.10

0.69 ± 0.11

0.77 ± 0.07

LDL-C (mmol/L)

0.27 ± 0.05

0.26 ± 0.07

0.34 ± 0.13

0.48 ± 0.10**

0.20 ± 0.03

0.25 ± 0.04*

0.26 ± 0.03*

0.25 ± 0.05

Glc (mmol/L)

5.19 ± 0.41

5.94 ± 0.26**

5.28 ± 0.77

5.93 ± 0.37*

5.64 ± 0.68

5.46 ± 0.50

6.03 ± 0.61

6.00 ± 0.37

LDH (U/L)

1436.50 ± 141.95

1243.36 ± 255.38

910.08 ± 165.81**

683.84 ± 202.51**

1143.87 ± 415.51

1007.39 ± 324.97

790.78 ± 253.54

749.79 ± 285.97

BUN (mmol/L)

4.88 ± 0.86

4.74 ± 0.93

4.00 ± 0.64

5.01 ± 0.60

4.76 ± 0.62

4.92 ± 0.39

5.70 ± 0.52*

4.96 ± 0.69

Cn (μmol/L)

46.60 ± 1.14

45.40 ± 4.83

44.60 ± 0.55**

45.20 ± 1.92

44.67 ± 1.97

44.00 ± 1.85

43.75 ± 2.25

45.75 ± 2.66

BUN/Cn

0.11 ± 0.02

0.11 ± 0.01

0.09 ± 0.02

0.11 ± 0.02

0.11 ± 0.02

0.11 ± 0.01

0.13 ± 0.01*

0.11 ± 0.02

UA (μmol/L)

89.00 ± 15.81

124.60 ± 8.68**

145.60 ± 14.93**

154.40 ± 17.14**

96.17 ± 17.01

111.75 ± 18.97

132.88 ± 14.26**

122.25 ± 25.79*

TBA (μmol/L)

21.78 ± 7.62

21.44 ± 5.74

18.82 ± 5.01

30.98 ± 7.49

21.97 ± 7.26

24.01 ± 6.79

28.9 ± 19.12

23.93 ± 9.87

  1. TP total protein, Alb albumin, Glo globulin, Tbil total bilirubin, Dbil direct bilirubin, Ibil indirect bilirubin, ALT alanine aminotransferase, AST aspartate aminotransferase, GGT gamma glutamyltransferase, ALP alkaline phosphatase, TG triglycerides, TC total cholesterol, HDL high-density lipoprotein, LDL low-density lipoprotein, Glc glucose, LDH lactate dehydrogenase, BUN blood urea nitrogen, Cn creatinine, UA uric acid, TBA total bile acid
  2. * Significant differences between treatment and control groups as judged by Student’s t-test using SPSS (*P < 0.05; **P < 0.001)
  3. aC, control group; S, small-size group (around 10 nm in diameter); M, mid-size group (around 20 nm in diameter); L, large-size group (around 40 nm in diameter); 6, 6 h post-dose; 48,48 h post-dose
  4. bEach value data represents the mean ± S.D