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Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: Nanoantibiotics containing membrane-active human cathelicidin LL-37 or synthetic ceragenins attached to the surface of magnetic nanoparticles as novel and innovative therapeutic tools: current status and potential future applications

Fig. 3

Improvement of anti-cancer activities of ceragenins CSA13, CSA-90 and CSA-192 after their immobilization on the surface of magnetic nanocarriers. a The level of lactate dehydrogenase release from lung carcinoma A549 and colon cancer DLD-1 cells after treatment with 10 µg/mL of ceragenin CSA-13 and its magnetic derivative. b IC50 values recorded for CSA-90, CSA-192 and their mixture with MNP against malignant melanoma A7, lung carcinoma A549, colon cancer DLD-1 and breast cancer MCF-7 cells. c Alterations in morphology and DNA fragmentation in colon cancer DLD-1 cells after their treatment with CSA-13 and MNP@CSA-13 at dose of 10 µg/mL for 24 h, investigated using phase contrast and fluorescence microscope, respectively

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