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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Insights into the angiogenic effects of nanomaterials: mechanisms involved and potential applications

Fig. 5

Reprinted with permission from [121]. Copyright 2014 American Chemical Society

YAP/TAZ control cardiac progenitor cell fate by acting as sensors of extracellular matrix composition. YAP/TAZ activity as transcriptional coactivators is regulated via their phosphorylation in the cytoplasm. Phosphorylated YAP/TAZ are thought to be inactive when retained in the cytoplasm. Nuclear shuttling is triggered in cardiac progenitor cells by substrate stiffening (a), cell spreading or migration (b), and modifications in substrate nanopattern (c). More importantly, the regulation of YAP/TAZ intracellular localization is required for cardiac progenitor cell fate decision (d).

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