Fig. 14

IOs and MF inhibit osteoclasts activity and affect integrins expression. Expression of master regulators of osteoclasts metabolism was investigated with qRT-PCR including: MMP-9 (a), CAII (b), CTK (c), c-fos (d), PU.1 (e). Additionally, expression of INTb-3 (g) and INTa-5 (h) was investigated. Results expressed as mean ± SD. Statistical significance indicated as asterisk (*) when comparing the results between corresponding bars representing MF− and MF+ groups, and as number sign (#) when comparing to CTRL MF−. #,*p < 0.05, ##p < 0.01, ***, ###p < 0.001