Fig. 6From: Surface chemistry governs the sub-organ transfer, clearance and toxicity of functional gold nanoparticles in the liver and kidneyTEM images of mouse liver tissues at 28Â days after i.v. injection of functionalized GNPs. PEG-GNPs were deposited in KCs (a1) and the secondary lysosomes of hepatocytes (a2); CS-GNPs were deposited in KCs (b1), in Ito cells in Disse space (b2); PEI-GNPs were deposited in secondary lysosomes of KCs (c1) and cytosol of HC (c2). KC Kupffer cells, EC endothelial cells, IC Ito cells, HC hepatocyte. GNP deposition was indicated by red arrowsBack to article page